Project TitlePulse Valve for Matrix-Assisted Ionization
Track CodeLSU-2017-032
Short Description

Pulsed Valve Matrix-Assisted Ionization (PV-MAI) is an innovative new ionization approach for matrix-assisted ionization mass spectrometer with high temporal resolution using an electrically actuated pulsed valve. Matrix and analyte samples are deposited on a thin metal foil and placed at the inlet of an ambient ionization mass spectrometer.  When the pulsed valve is actuated, a short puff of high pressure gas impinges on the foil and ejects particulate from the sample on the opposite side. Highly charged ions are formed from the particles at the mass spectrometer inlet. Using this source, multiple charged protein ions are produced within a selectable 4 second time window.

Posted DateSep 20, 2017 4:49 PM


  • Greater degree of control (temporal and spatial) compared to methods that produce ions using mechanical shock.
  • Approximately 100 times less costly than pulsed laser ionization, which can cost in the tens of thousands of dollars.
  • Capable of ionizing sample material within 5 seconds of pulse valve actuation.
  • Produces highly charged ions, unlike Matrix-Assisted Laser Desorption Ionization (MALDI).
  • Imaging at both ambient pressure and under vacuum. 


  • Automated sampling
  • Precision MAI imaging of biological samples
  • Tissue analysis

Licensing Contact


File Name Description
(LSU-2017-032)(Murray)(Pulsed Valve MAI) Tech Summary.pdf LSU-2017-032 Technology Summary Download

Intellectual Property

Patent Number Issue Date Type Country of Filing
Patent Pending None Provisional United States